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Niraparib Tosylate Monohydrate

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Name

Niraparib Tosylate Monohydrate

Purpose
Antineoplastic Agents;Enzyme Inhibitors;Poly(ADP-ribose) Polymerase Inhibitors
CAS No
1613220-15-7
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Description

Niraparib Tosylate Monohydrate 

Chemical Names: Niraparib tosylate monohydrate; UNII-195Q483UZD; 195Q483UZD; 1613220-15-7; SCHEMBL15777871; EX-A1766 ;2H-Indazole-7-carboxamide, 2-(4-(3S)-3-piperidinylphenyl)-, 4-methylbenzenesulfonate, hydrate (1:1:1).
 
CAS No.:1613220-15-7
 
Molecular Formula: C26H30N4O5S
 
Molecular Weight: 510.609 g/mol
 
Purity: 99%
 
Use :Niraparib Tosylate Monohydrate is an orally bioavailable, hydrated, tosylate salt form of niraparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.
 

 

 
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暂未实现,敬请期待
暂未实现,敬请期待